The present invention belongs to the field of pharmaceutical chemistry, and in particular relates to a type of phenyl-substituted triazine compounds inhibiting epidermal growth factor receptor tyrosine kinase, compositions comprising the compounds, and uses of said compounds or compositions as the medicament for treatment of tumors. The compounds of the present invention have a good inhibition of mutant EGFR kinase, exhibit excellent selection, and have a prospect of becoming a drug having specific effect on resistant tumors, specifically those EGFR-mutated resistant tumors.本發明屬於醫藥化學領域,具體涉及一種具有表皮生長因子受體(EGFR)抑制作用的苯基取代的三嗪類化合物、含有該化合物的藥物組合物,以及所述化合物或藥物組合物作為癌症治療藥物的用途。本發明提供的化合物對突變型EGFR激酶具有良好的抑制活性,表現出優異的選擇性,有望成為對抗藥性腫瘤,尤其是對EGFR突變導致耐藥的腫瘤具有特異療效的藥物。
