LEE, SANG HYUN,KITAGAWA, MAYUMI,EPSTEIN, DAVID MICHAEL
申请号：
CA3046604
公开号：
CA3046604A1
申请日:
2017.12.08
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to compounds and their use in modulating the Ras/Raf/MEK/ERK and PI3K/Akt/mTOR signaling pathways to protect normal cells in scenarios such as chemotherapy to kill cancer cells. More particularly, the compounds inhibit phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) and/or increase phosphoinositide 3-kinase-interacting protein 1 (PIK3IP1). Also provided are methods for identifying such compounds, methods of treatment using same and other uses.
