LEE HEE-YONG,KIM JUNG-SOO,SHIN EUN-HO,KIM SEONG-KYU,SEOL EUN-YOUNG,BAEK MI-JIN,BAEK MI-YOUNG,CHAE YEON-JIN,CHOI HO-IL
申请号：
IN2632/MUMNP/2008
公开号：
IN253935B
申请日:
2008.12.10
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
Disclosed is a process of preparing sustained release microspheres, containing a biodegradable polymer as a carrier and a drug, using spray drying. The process comprises preparing a solution, suspension or emulsion containing a biodegradable polymer, a drug and a solvent spray drying the solution, suspension or emulsion and suspending spray-dried microspheres in an aqueous solution containing polyvinyl alcohol to remove the residual solvent and increase the hydrophilicity of the microsphere surface. The process enables the preparation of microspheres having high drug encapsulation efficiency, almost not having a toxicity problem due to the residual solvent, and having good syringeability. The microspheres prepared according to the present invention release an effective concentration of a drug in a sustained manner for a predetermined period when administered to the body, and are thus useful in the treatment of diseases.
