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New crystalline form VI of agomelatine, preparation method and application thereof
专利权人:
LES LABORATOIRES SERVIER
发明人:
SHAN HANBIN,ZHANG PENG,YUAN ZHEDONG
申请号:
AP201105914
公开号:
AP3049A
申请日:
2010.03.09
申请国别(地区):
AP
年份:
2014
代理人:
摘要:
The invention provides a new crystalline form of agomelatine, preparation and use thereof. The X-ray powder diffraction diagram of the agomelatine crystalline form shows main peaks at the diffraction angles 2¸ 11.13°, 11.82°, 17.49°, 18.29°, 19.48°, 19.72°, 20.50°, 21.76°, 22.54°, 22.97°, 24.56°, 25.36°, 27.16° and 31.93°. Said new crystalline form is characterized by high purity, stability and good reproducibility, and thus is advantageous for the pharmaceutical formulation. In addition, the stability and solubility of said crystalline form are also superior over the several existing crystalline forms.
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