The present invention relates to a transdermal therapeutic system for cutaneous administration of fampridine. The system includes an active ingredient-impermeable backing layer, a pressure-sensitive adhesive reservoir layer and optionally a detachable protective layer. The pressure-sensitive adhesive reservoir layer is formed from fampridine and at least one matrix polymer containing no free carboxylic acid and/or carboxylate groups, with the content of fampridine in the matrix polymer being <；5% by weight. On account of the low loading and also the lack of carboxylic acid and/or carboxylate groups in the reservoir layer, it is ensured that the systems administer the active ingredient substantially at higher administration rates than is known in the prior art, and compared to known systems a comparable thermodynamic activity of the active ingredient is achieved. The present invention further relates to a process for producing corresponding transdermal therapeutic systems.
