Pharmaceutical composition containing 1,2-dithiolthione derivatives for prevention and treatment of diseases caused by LXR-alpha overexpression

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专利权人:

エスエヌユー アール アンド ディービー ファウンデーション

发明人:

キム、サン ゴン,キ、スン ファン,ファン、ソン ファン

申请号：

JP2011520000

公开号：

JP5300979B2

申请日:

2009.07.30

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

Provided is a pharmaceutical composition that contains a 1,2-dithiolthionederivative, and is effective to prevent and treat a disease caused by overactivity of a liver X receptor&alpha； (LXR&alpha；) or a sterol response element binding protein (SREBP-1). Specifically, the pharmaceutical composition includes 1,2-dithiolthione derivatives such as 4-methyl-5-(2-pyrazinyl)-1,2-dithiol-3-thione, 3-methyl-1,2-dithiol-3-thione, or 5-(6-methoxypyrazinyl)-4-methyl-1,2-dithiol-3-thione. The pharmaceutical composition is effective for preventing and treating hypertension caused by renin, aldosteronism, adrenoleukodystrophy, glomerulosclerosis, proteinuria, nephropathy, liver steatosis, hypertriglyceridemia or hyperreninemia.

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中国工程科技知识中心

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