Provided is a method (200) for generating a combined anatomical model of a heart. The method comprises receiving (220) a non-contrast agent-enhanced ultrasound image of a left ventricular region of the heart and receiving (240) a contrast agent-enhanced ultrasound image of the left ventricular region of the heart. Image registration (260) is performed on the respective non-contrast agent-enhanced and contrast agent-enhanced ultrasound images, such that the respective images are aligned. Combined segmentation (270) of the aligned non-contrast agent-enhanced and contrast agent-enhanced ultrasound images is then carried out to generate the combined anatomical model. Further provided is a processor arrangement adapted to implement the method and an ultrasound system comprising the processor arrangement. A computer program product comprising computer program code means adapted to implement the method is also provided.
