The embodiments relate to an angiographic examination method for generating a 2D projection image. The method includes: (1) acquiring a volume dataset, (2) reconstructing a 3D volume from the volume dataset, (3) forward-projecting for generating a virtual vessel projection, (4) deriving a binary vessel mask, (5) acquiring at least one current 2D projection image, (6) combining the binary vessel mask with the at least one current 2D projection image to form a current mask, (7) thresholding the current mask to form a current binary mask, (8) back-projecting the current binary mask into the 3D volume to form a mask volume, (9) threshold value segmenting the mask volume in order to generate a final virtual vessel volume, and (10) subtracting a projection of the vessel volume from the current 2D projection images to generate a selective, overlay-free visualization of the body region of interest by selectable parameters.