Knot placement devices and methods can improve the ease for a user and/or success of ejecting a knot having a knot body and a plug, cutting suture and/or releasing the cut suture. The knot placement device can have an incremental rotational feature to cut the suture. The knot placement device can include first and second actuators configured for forming and ejecting a knot. The second actuator can be reversed in its position to release suture(s) caught within the device.
