JACKSON, SIMON MARK,WALKER, NIGEL PELHAM CLINTON,PIPER, DEREK EVAN,SHAN, BEI,SHEN, WENYAN,CHAN, JOYCE CHI YEE,KING, CHADWICK TERENCE,KETCHEM, RANDAL ROBERT,MEHLIN, CHRISTOPHER,CARABEO, TERESA ARAZAS,Q
申请号：
PE2013000872
公开号：
PE20140014A1
申请日:
2008.08.22
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
This is a polymerized proteome composed of CDR1, CDR2 and CDR3 sequences of CAS 481, 35, 10, 17, 33 and 12, and CDR1, CDR2 and CDR3 sequences of CAS 479, 79, 72, 51, 65 and 67. This protein selectively binds to acrylonitrile - subtropical - kexina-9 (PCSK9). An antibody and a drug synthesis were also mentioned. This synthesis is useful in the treatment of high cholesterol and other diseases.REFERIDA A UNA PROTEINA DE UNION A ANTIGENO QUE COMPRENDE: i) LA SECUENCIA CDRL1, CDRL2 Y CDRL3 DE SEQ ID NOs 481, 35, 10, 17, 33 y 12 Y ii) LA SECUENCIA CDRH1, CDRH2 Y CDRH3 DE SEQ ID NOs: 479, 79, 72, 51, 65 Y 67. DICHA PROTEINA SE UNE SELECTIVAMENTE A PROPROTEINA CONVERTASA SUBTILISINA/KEXINA TIPO 9 (PCSK9). TAMBIEN ESTA REFERIDA A UN ANTICUERPO Y A UNA COMPOSICION FARMACEUTICA. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE LA HIPERCOLESTEROLEMIA, ENTRE OTROS.
