A drug delivery blade for delivering a drug depot to a treatment site in a patient is disclosed. The drug delivery blade includes a shaft defining a longitudinal axis of the blade a lumen that extends longitudinally from a proximal end of the shaft to a distal end of the shaft a first beveled cut that forms a sharpened tip at the distal end of the shaft and a flared portion near the distal end of the shaft. The flared portion of the blade includes two radially extending blade segments having sharpened leading edges that allow the drug delivery blade to cut tissue when the blade is advanced toward a treatment site. Methods of using the drug delivery blade are also disclosed.