UPOTREBA KOMBINACIJE KAO INHIBITORA SINUSNE STRUJE I INHIBITORA ENZIMA KONVERZIJE ANGIOTENZINA ZA LIJEČENJE ZATAJENJA SRCA S OČUVANOM SISTOLIČKOM FUNKCIJOM
Combination (I) comprises a selective and specific sinusal I f(mixed sodium ion-potassium ion inward current) current inhibitor (A) and an angiotensin converting enzyme inhibitor (B). An independent claim is included for pharmaceutical compositions comprising: ivabradine, in the form of hydrochloride or its hydrate or crystalline forms, and perindopril, in the form of salt of tert-butylamine or arginine or their hydrates or crystalline forms, alone or in combination with one or more excipient. ACTIVITY : Cardiant; Cardiovascular-Gen.; Vasotropic; Antianginal; Antiarrhythmic. MECHANISM OF ACTION : Sinusal I fcurrent inhibitor; Angiotensin converting enzyme inhibitor.text