GOEHRING, RICHARD R.,MATSUMURA, AKIRA,SHAO, BIN,TAODA, YOSHIYUKI,TSUNO, NAOKI,WHITEHEAD, JOHN WILLIAM FRANK,YAO, JIANGCHAO,FUCHINO, KOUKI
申请号：
ES08806986
公开号：
ES2534546T3
申请日:
2008.08.29
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Compounds according to Formula (II): ** Formula ** or a pharmaceutically acceptable derivative thereof wherein: Y1 is O； Q is selected from heteroaryl (5 or 6 member) or fused benzo； each R2 is independently selected from: (a) -halo, -CN, -NO2, -OT3, -C (>； = O) T3, -C (>； = O) OT3, -C (>； = O) N (T1 ) (T2), -S (>； = O) 3H, -S (>； = O) T3, -S (>； = O) 2T3, - S (>； = O) 2N (T1) (T2), -N ( T1) (T2), -N (T3) C (>； = O) T3, -N (T3) C (>； = O) N (T1) (T2), -N (T3) S (>； = O) 2T3 , or -N (T3) S (>； = O) 2N (T1) (T2)； or (b) -C1-C6 alkyl, -C2-C6-alkenyl, -C2-C6-alkynyl, -C1-C6-alkoxy, -C3-C7-cycloalkyl, -C6-C14-cycloalkyl ), - tricycloalkyl (C8-C20), -cycloalkenyl (C5-C10), -bicycloalkenyl (C7-C14), -trichloralkenyl (C8-C20), -heterocycle (5 or 6 members), or -bicycloheterocycle (7 10 members), each of which is unsubstituted or substituted with 1, 2 or 3 independently selected R8 groups； or (c) -phenyl, -naphthalenyl, -aryl (C14), or -heteroaryl (5 or 6 members), each of which is unsubstituted or substituted with 1, 2 or 3 independently selected R7 groups； a is an integer selected from 0, 1 or 2； the dashed line in the 6-membered nitrogen-containing ring that is fused to group Q indicates the presence or absence of a bond, and when that dashed line indicates the presence of a bond, then R3 and R4 are absent ； R3 is selected from: (a) -H； or (b) -C1-C4 alkyl which is unsubstituted or substituted with 1, 2 or 3 groups independently selected from -OH, -C1-C4 alkoxy, -N (R6) 2, -C ( >； = O) OR9, or -C (>； = O) N (R6) 2； or (c) -C3-C7 -cycloalkyl which is not substituted or substituted with 1, 2 or 3 groups independently selected from -OH, -C1-C4 alkyl, -C1-C4 alkoxy, -N (R6) 2, -C (>； = O) OR9, or -C (>； = O) N (R6) 2； each R4 is independently selected from: (a) -H； or (b) -halo, -CN, or -NO2； or (c) -X, -C1-C6 alkyl-X, -heterocycle (5 or 6 members) -X, or -heterocycle (5 or 6 members) -C1-C6 alkyl -X； or (d) -C (>； = Y) CN, -C (>； = Y) X, -C
