KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;국민대학교산학협력단;한국화학연구원;KOOKMIN UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION
发明人:
CHOI, SANG UN,최상운,RYU, SHI YONG,유시용,KIM, YOUNG SUP,김영섭,CHOI, CHUN WHAN,최춘환,CHOI, YEON HEE,최연희,CHA, MI RAN,차미란,KIM, YOUNG KYOON,김영균
申请号：
KR1020110033674
公开号：
KR1020120116115A
申请日:
2011.04.12
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: An anticancer drug composition including resveratrol derivative compound separated from grape stem shell is provided to prevent and treat all kinds of cancers including lung cancer, ovarian cancer, melanoma, central nervous system tumor, colon carcinoma, and leukemia. CONSTITUTION: An anticancer drug composition includes vitisinol C, vitisinol E, cis-vitisin A, vitisin B, vitisin C, a pharmaceutically acceptable salt and isomer or a mixture thererof, and grape stem shell extract including thereof as an active ingredient. The grape stem shell extract is obtained by extracting methanol, methanol aqueous solution, ethanol, ethanol aqueous solution, butanol, dichloromethane, ethyl acetate or a mixture thereof. The cancer is lung cancer, ovarian cancer, melanoma or colon carcinoma. A health enhancement food having cancer cell growth inhibition efficacy contains vitisinol C, vitisinol E, cis-viticin A, viticin B, viticin C, pharmaceutically acceptable salt, isomer or a mixture thereof, and grapes stem shell extract including the same. The food is in beverage form. The grape stem shell extract is obtained by the following steps: extracting the grape stem shell by methanol and suspending the obtained extract in distilled water； partitioning thereof by dichloromethane； and extracting the obtained water layer by ethyl acetate.본 발명은 포도(vitisvinifera) 줄기 껍질 추출물 및 이로부터 분리 정제된 레스베라트롤 화합물인 비티시놀 C(vitisinol C), 비티시놀 E(vitisinol E), 시스-비티신 A(cis-vitisin A), 비티신 B(vitisin B), 비티신 C(vitisin C) 및 이들의 혼합물로 이루어진 그룹으로부터 선택된 어느 하나를 약제학적으로 허용되는 담체와 함께 함유하는 항암제 조성물에 관한 것으로, 본 발명의 조성물은 폐암, 난소암, 흑색종, 중추신경계종양, 결장암, 백혈병 등 각종 악성종양의 예방 및 치료제로 사용될 수 있다.
