CONJUGUÉ D'UN POLYMÈRE, D'UN AGENT ANTI-ANGIOGENÈSE ET D'UNE FRACTION DE CIBLAGE ET UTILISATIONS DE CE CONJUGUÉ POUR TRAITER DES MALADIES ANGIOGÉNIQUES OSSEUSES

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专利权人:

RAMOT AT TEL-AVIV UNIVERSITY LTD.;THE UNIVERSITY OF UTAH RESEARCH FOUNDATION

发明人:

SATCHI-FAINARO, RONIT,SEGAL, EHUD,KOPECEK, JINDRICH,KOPECKOVA, PAVLA,PAN, HUAIZHONG

申请号：

EP09750279

公开号：

EP2300021A4

申请日:

2009.05.21

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed. Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and an oligoaspartate bone targeting agent, and processes of preparing same, are further disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment and monitoring of bone related disorders are also disclosed.

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