The present invention provides a vesicle-containing composition having an excellent stability in the presence of water-soluble medicinal agent. A vesicle-containing composition of the present invention is characterized by comprising:(A) a silicone-based surfactant,(B) one or more anionic surfactants selected from polyoxyethylene alkyl (12 to 15) ether phosphate, acyl methyl taurate and acyl glutamate in an amount of 0.001 to 0.2 mass %,(C) a polar oil having IOB of 0.05 to 0.80 and/or silicone oil, and(D) water containing a water-soluble medicinal agent in an amount of 0.5 to 5 mass % based on the composition,wherein the (A) silicone-based surfactant forms vesicles the (B) anionic surfactant(s) attaches to a surface of the vesicles and the (C) polar oil and/or silicone oil is present within a bilayer membrane of the vesicles.
