Barry A. Polisky,Roger C. Adami,Michael V. Templin,Pierrot Harvie,Rachel E. Johns,Jaya S. Giyanani,Michael E. Houston, JR.
申请号：
US14682314
公开号：
US20150209283A1
申请日:
2015.04.09
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Processes and compositions for liposomal delivery of therapeuticals prepared by contacting an aqueous solution of an active agent with a solution of liposome-forming components containing one or more DILA2 amino acid compounds or lipids in organic solvent to form an impinging stream. A protocol including flow rates, pH, and an incubation period are used to control formation of liposomal components for therapeutic applications. The impinging stream may be collected and incubated to prepare a liposomal formulation which encapsulates the active agent. The composition can be quenched with buffer and filtered by tangential flow and diafiltration and other means for finishing as a pharmaceutical composition.
