This invention relates to a bilayer pharmaceutical compositions comprising fixed-dose combinations of a dipeptidyl peptidase-4 inhibitor and simvastatin, methods of preparing such pharmaceutical compositions, and methods of treating Type 2 diabetes with such pharmaceutical compositions.本發明係關於一種雙層醫藥組合物,其包含二肽基肽酶-4抑制劑與史伐坦丁之固定劑量組合;製備該等醫藥組合物之方法;及用該等醫藥組合物治療第2型糖尿病之方法。