Method for producing conjugates of polysaccharides and polynucleotides

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专利权人:

Supramol Parenteral Colloids GmbH

发明人:

Sommermeyer, Klaus

申请号：

AU2012200147

公开号：

AU2012200147A1

申请日:

2012.01.11

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

#$%^&*AU2012200147A120120202.pdf#####Abstract The invention relates to a method for producing a conjugate of a polynucleotide and a polysaccharide comprising the steps: a) provision of an aldonic acid of the polysaccharide or of a derivative thereof b) reaction of the aldonic acid with an alcohol derivative, preferably a carbonate derivative of an alcohol, to form an aldonic acid ester, preferably an activated aldonic acid ester and c) reaction of the aldonic acid ester with the polynucleotide, wherein the polynucleotide comprises a functional amino group. The reaction of the aldonic acid with the alcohol derivative in step b) takes place in a dry aprotic polar solvent.

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