A protection device for a mobile phone with a medicine box includes a accommodating unit for accommodating medicines, and a protection unit arranged on the accommodating unit. The protection unit includes two clamping pieces respectively arranged on both sides of the accommodating unit, and at least one bracket pivotally arranged on the accommodating unit. The two clamping pieces are used for clamping both sides of a mobile phone. The accommodating unit can be pivoted relative to the accommodating unit to support the accommodating unit. Since in the 3C era, mobile phones have become almost everyone’s daily necessities and they will also be carried with them. Therefore, this case combines the pill box with the mobile phone case so that users can carry the pill box together when they go out with the mobile phone, which can avoid using it. The user forgot to carry the pill box to ensure that the user can take the medicine on time. And the design of the bracket can make this case a mobile phone holder, with multiple uses.一種具有藥盒的手機保護裝置,包含一用以置藥物的容置單元,及一設置於該容置單元上的保護單元。該保護單元包括兩個分別設置於該容置單元兩側的夾持件,及至少一樞設於該容置單元的支架,該二夾持件用以夾持一手機的兩側,該支架能相對於該容置單元樞轉而撐立該容置單元。由於在3C 時代,手機幾乎已成為每個人的生活必需品,也會隨身攜帶,因此本案將藥盒與手機殼結合,讓使用者在攜帶手機出門時就能一併攜帶藥盒,能避免使用者忘了攜帶藥盒的問題,確保使用者能按時服藥。而該支架的設計能使本案成為手機架,具備多種用途。