Anita Chaudhari,Ananda Chakrabarty,Tapas Das Gupta,Arsenio Fialho,Tohru Yamada,Yonghua Zhu
申请号：
US14817063
公开号：
US20160151452A1
申请日:
2015.08.03
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system in mammalian cells. Specifically, the invention relates to compositions and methods that use cupredoxins, such as azurin, rusticyanin and plastocyanin, and variants, derivatives and structural equivalents thereof, to treat cancer in mammals. The invention specifically includes mutants with altered Eph binding constants and selectivities.
