MOSS, JONATHAN,LINGEN, MARK,SINGLETON, PATRICK A.,GARCIA, JOE G.N.,YUAN, CHUN-SU
申请号:
CA2649710
公开号:
CA2649710C
申请日:
2007.04.17
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that associated with angiogenesis, using opioid antagonists, including, but not limited to, those that are peripherally restricted antagonists, such as methylnaltrexone or alvimopan. The disorders to be treated alone or in combiantion with for instance - anticancer agents (5-f luorouracil or bevacizumab) are i.a. cancer, diabetes, sickle cell anemia, vascular wound, proliferative retinopathy.