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UTILISATION D'ANTAGONISTES DES OPIOIDES POUR ATTENUER LA PROLIFERATION ET LA MIGRATION DES CELLULES ENDOTHELIALES
专利权人:
THE UNIVERSITY OF CHICAGO
发明人:
MOSS, JONATHAN,LINGEN, MARK,SINGLETON, PATRICK A.,GARCIA, JOE G.N.,YUAN, CHUN-SU
申请号:
CA2649710
公开号:
CA2649710C
申请日:
2007.04.17
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that associated with angiogenesis, using opioid antagonists, including, but not limited to, those that are peripherally restricted antagonists, such as methylnaltrexone or alvimopan. The disorders to be treated alone or in combiantion with for instance - anticancer agents (5-f luorouracil or bevacizumab) are i.a. cancer, diabetes, sickle cell anemia, vascular wound, proliferative retinopathy.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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