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ANTAGONISTAS DO RECETOR DE A2A PARA UTILIZAÇÃO NO TRATAMENTO DE DISTÚRBIOS DE MOVIMENTO
专利权人:
KYOWA HAKKO KOGYO CO.; LTD
发明人:
HIROSHI KASE,AKIRA KARASAWA,AKIHISA MORI,YUTAKA WAKI,YUTAKA OHSAWA,YOSHIHISA KUWANA
申请号:
PT15165962
公开号:
PT2942082T
申请日:
2003.01.28
申请国别(地区):
PT
年份:
2019
代理人:
摘要:
The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A 2A receptor antagonists to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of L-DOPA in patients receiving L-DOPA therapy in the treatment of Parkinson's disease. The present invention further provides methods and compositions for treating Parkinson's disease patients with sub-clinically effective doses of L-DOPA by combining L-DOPA treatment with an effective amount of one or more adenosine A 2A receptor antagonists (i.e., L-DOPA sparing effect). The present invention further provides methods of effective treatment of Parkinson's disease by co-administering at least one adenosine A 2A receptor antagonist, L-DOPA and a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor. The present invention further provides methods of prolonging effective treatment of Parkinson's disease by administering an adenosine A 2A receptor antagonist singly or together with a dopamine agonist, and/or a COMT inhibitor, and/or a MAO inhibitor without prior or subsequent administration of L-DOPA, delaying or removing on-set of L-DOPA motor complication.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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