The field of this invention is measuring efficacy of cancer treatments. In particular the fields of this invention include studies of drug efficacy, use of animals in medical studies, use of animals in vivariums, and use of rodents, particularly mice. Cells from a neoplasm are injected into subject test animals in a specific organ or a specific location of a specific organ, such as the brain. Some of the subject animals receive therapeutic treatments. The behavior of the animals is observed using fully automatic, continuous monitoring using per-cage sensors, where behavior recording is free of human, manual actions. Observed behavior is consistent with healthy or unhealthy behaviors specific to the injection site. Both positive and negative baseline behaviors are collected, typically using the same system or method. Efficacy is measured by comparing treatments under test to both the positive and negative baselines, using multi-dimensional analysis.
