Silvia Muro Galindo,Vladimir R. Muzykantov,Edward Howard Schuchman
申请号：
US14516231
公开号：
US09655953B2
申请日:
2014.10.16
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to compositions and methods for delivering lysosomal proteins. The compositions and methods described herein permit the targeted delivery of exogenous lysosomal proteins to cell surface proteins that allow their internalization via non-clathrin pathways. The present invention further relates to the use of the compositions and methods for enzyme replacement therapy of lysosomal storage diseases. Nucleic acids, recombinant cells and kits useful for making and using the compositions of the invention are also provided.
