The invention aims to disclose a preparation method of a bone defect filling guide apparatus, which provides a scanning image, which includes a normal bone area and a bone defect area； reading the scanning image to reconstruct a three-dimensional image； specularly shooting the normal bone area of the three-dimensional image to the bone defect area to generate a composite image； analyzing the normal bone area and the bone defect area according to the composite image The technical means of the invention includes obtaining a bone reconstruction data from the contour of the domain, and constructing at least one bone filling guide according to the bone reconstruction data.Thus, the implants / prostheses needed for joint replacement can be prepared.本發明旨在揭露一種骨缺損補骨導引器具之製備方法，其以提供一掃描圖像，其包含一骨正常區域以及一骨缺損區域；讀取該掃描圖像重建一三維圖像；鏡射該三維圖像之該骨正常區域至該骨缺損區域產生一合成圖；依據該合成圖分析該骨正常區域以及該骨缺損區域之輪廓，取得一骨重建數據；以及依據該骨重建數據建構至少一補骨導引件等步驟完成本發明之技術手段。藉此製備關節再置換手術所需之植入物/假體。
