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A NEW PHARMACEUTICAL COMBINATION COMPRISING AN ANTICANCER DRUG PACLITAXEL AND BIOACTIVE BIOENHANCER PIPERINE FOR ENHANCING BIOAVAILABILITY OF PACLITAXEL
专利权人:
发明人:
VINOD DOMAJI RANGARI,MEHA NARENDRA MOTIWALA
申请号:
IN1741/MUM/2009
公开号:
IN2009MU01741A
申请日:
2009.07.30
申请国别(地区):
IN
年份:
2014
代理人:
摘要:
The present invention relates to a bioenhancing/bioavailability-facilitating composition comprising an anticancer drug paclitaxel and bioactive bioaenhancer piperine. Oral bioavailability of paclitaxel is low because of induction of P-glycoprotein and cytochrome P-3A4. Piperine inhibits the action mediated by P-glycoprotein and cytochrome P-3A4. The combination is characterized in having clinically significant increased bioavailability when compared to paclitaxel alone. Enhanced bioavailability of Paclitaxel results in the reduction of both dosages and dose-related side effects. Thus without resorting to the prodrug method a new pharmaceutical composition comprising piperine and paclitaxel with significant increase in bioavailability of paclitaxel is herein disclosed.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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