ALONSO - BEDATE CARLOS,SOTO - ALVAREZ MANUEL,PARODY - DE LA FUENTE NURIA,PICO DE COAÑA - SUÁREZ YAGO
申请号：
NZ60995211
公开号：
NZ609952A
申请日:
2011.11.10
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of: i. nucleotide sequences encoding a polypeptide comprising an amino acid sequence that has at least 50&thinsp；% sequence identity with the amino acid sequence of SEQ ID NO:1 over its entire length, ii. nucleotide sequences comprising a nucleotide sequence that has at least 50&thinsp；% sequence identity with the nucleotide sequence of SEQ ID NO:2 over its entire length, iii. nucleotide sequences the complementary strand of which hybridises to a nucleic acid molecule of sequence of (i) or (ii) and iv. nucleotide sequences which differ from the sequence of a nucleic acid molecule of (iii) due to the degeneracy of the genetic code, operably linked to a nucleotide sequence encoding an antigen, wherein the nucleic acid molecule encodes a polypeptide which is able to elicit an antigen-specific immune response in a subject, wherein the nucleic acid molecule is free of a sequence encoding for a polypeptide which is identical to SEQ ID NO: 3 over its entire length； wherein the sequences are as disclosed in the specification.
