АБИАД Морис (US),ДАНИ Бхас (US),ШАЛАЕВ Евгений (US)
申请号：
RU2019110875
公开号：
RU2019110875A
申请日:
2017.09.13
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
Pharmaceutical compositions that stabilize a Clostridial toxin active ingredient are described. The compositions can be liquid or solid compositions, and comprise a surfactant and an antioxidant. In some embodiments, the compositions comprise a surfactant selected from a poloxamer and a polysorbate； an antioxidant selected from methionine, N-acetyl cysteine, ethylenediaminetetraacetic acid and combinations thereof； and, optionally, a tonicity agent and/or a lyoprotector selected from, for example, trehalose and sucrose.
