The present invention provides a method of treatment of a neuropsychiatric disorder characterized by repetitive pheno-type, comprising administering to a human or non-human subject in need thereof a therapeutically effective dose of a pharmaceutical composition comprising at least one active agent selected from a group of active agents comprising CB2 receptor inverse agonists and mixed CB2/SERM ligands. The present invention further provides pharmaceutical compositions comprising 4′；-0-methylhonokiol, raloxifene, and their derivatives, HU-308 and/or BCP.
