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A method of production of a cartilage-like biomaterial designed for reconstructive surgery
专利权人:
发明人:
申请号:
EP11001896.7
公开号:
EP2371401A3
申请日:
2011.03.08
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
A method of production of a cartilage-like biomaterial designed for implants for reconstructive surgery by using microbial cellulose produced in a stationary culture of bacterium Gluconacetobacter xylinus consists in cultivation of the bacterium in a flat bioreactor or polyethylene tubes, modeling of produced and purified cellulose into spatial construction with desired shape and modification of the latter by treatment with 30% aqueous solution of sodium hydroxide, rinsing with distilled water, treatment with 10% aqueous solution of acetic acid and repeated rinsing with distilled water until pH of cellulose material reaches 5.6-6.8.
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