COMPOSITIONS ET MÉTHODES POUR L'INHIBITION DE LA FORMATION ET DE LA SIGNALISATION DU COMPLEXE CRIPTO/GRP78

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专利权人:

RESEARCH DEVELOPMENT FOUNDATION

发明人:

GRAY, PETER, C.,SHANI, GIDI,KELBER, JONATHAN, A.,VALE, WYLIE

申请号：

EP09825562

公开号：

EP2350131A4

申请日:

2009.11.09

申请国别(地区):

EP

年份:

2013

代理人:

摘要：

The present invention provides methods compositions and methods for treating a hyperproliferative disease comprising disrupting Cripto/GRP78 complex formation in a hyperproliferative cell. In certain embodiments, an antibody and/or siRNA may be used to inhibit Cripto/GRP78 binding, optionally coupled with other cancer therapies. Also provided are methods for identifying therapeutic compounds which can selectively inhibit Cripto/GRP78 binding.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/