Zonghai Li,Huamao Wang,Hua Jiang,Bizhi Shi,Jianren Gu,Shengli Yang
申请号：
US13497763
公开号：
US08506963B2
申请日:
2009.09.22
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides specific binding proteins and the uses thereof. Particularly, the present invention provides a monoclonal antibody which can effectively bind to epidermal growth factor receptor variant type III (EGFRvIII) or can partially bind to the epidermal growth factor receptor (EGFR) over-expressed in cells, but not bind to EGFR normally-expressed in cells. Furthermore, the present invention said antibody has obvious therapeutic effect on a tumor cell line expressing the EGFRvIII. The invention also provides a method for preparing said monoclonal antibody and a pharmaceutical composition comprising said monoclonal antibody.
