A pramipexole transdermal patch for treatment of neurological disorders including Parkinson’s disease that may be administered on a daily basis. The pramipexole transdermal patch of the present invention preferably comprises a drug-containing layer that comprises pramipexole or a pharmaceutically acceptable salt thereof at 2% to about 15% by weight of the drug-containing layer and at least two acrylic polymers wherein each polymer may further comprise carboxyl and/or hydroxyl functional groups. The pramipexole transdermal patch of the present invention may further comprise two or more permeation enhancers with combined pramipexole solubility of greater than 50 mg/mL.一種用於治療包含帕金森氏症的神經性疾病的普拉克索經皮貼片,其可每日投予。本發明的普拉克索經皮貼片較佳係包括含藥層,其包括普拉克索或其醫藥上可接受的鹽,其佔該含藥層重量約2%至約15%,以及至少二個丙烯酸聚合物,其中各個聚合物可另包括羧基與/或羥基官能基團。本發明的普拉克索經皮貼片可另包括具二或多種滲透增強劑,具有結合的普拉克索溶解度為大於50mg/mL。
