The invention features delivery systems for delivering a gastrointestinal device into the gastrointestinal tract of a patient and anchoring the gastrointestinal device with an anchor (e.g., a disintegrable anchor). Also provided are methods of delivering such gastrointestinal devices using the delivery systems described herein. The methods and delivery systems of the invention can be used for treatment of metabolic diseases, such as type 2 diabetes, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), obesity, and related comorbidities thereof.
