A method of treating the symptoms of spasticity comprises implanting a reservoir-based drug delivery composition into a subject to systemically deliver a therapeutically effective amount of tizanidine to the subject for a long period of time (e.g., one month or one year). The drug delivery composition may include a rate-controlling excipient (e.g., an elastomeric polymer) defining a reservoir containing at least one discrete solid dosage form (e.g., one or more pellets), which includes tizanidine free base and optionally, a sorption enhancer.本發明揭示一種治療痙攣之症狀之方法，其包含將基於儲集囊之藥物傳遞組合物植入個體中以持續長久時期(例如一個月或一年)向該個體全身性傳遞治療有效量之替紮尼定。該藥物傳遞組合物可包括界定含有至少一種分開之固體劑型(例如一或多個丸粒)之儲集囊之速率控制賦形劑(例如彈性體聚合物)，該分開之固體劑型包括替紮尼定游離鹼及視情況選用之吸收增強劑。
