Heterocyclic substituted azetidinil of Cyclohexyl Derivatives, Pharmaceutical compositions containing them, a process for preparing and Use thereof in disorders of the digestive, respiratory and central nervous system, among others
1. Claim 1: a formula compound (1), wherein: A is the remaining part (2) of the formula group；Nnhc 3 (3) or NRC 3 (3) nnnrc 3 (3) or NRC 3 (3) nnn-4, C (o) nhch2ph (OCH3) 2, -C (OH) (CH2CH = CH2) 2,3,6-dihydropiran-2-il, 2,5-dihydrofuran-2-il o, tetrahydropirani, cycloopentilo, cycloopenta Nile, cyclohexanio, tetrahydran-2-il o, cyclohexane, a group of unreplaced or unreplaced C1-6 residues, of which up to two can be replaced.Liluox2, lil2, lil2, lil2, liluox3, Li3, ch2nhco tar c1-3, N3, sch3, S (o) CH3, so2ch3 and - CN, the second C1-6 tar substitute is oh, in which case, phenyl or isopropene can be replaced by a substitute selected from the following groups: oh-cn, CH2OH, o-tar C1-4, NH2, nh-tar C1-4, o-tar C1-4, C (or) C1-4, co2-tar C1-4, C (or) nhh-c14-c14-tar, coh4-c14-tarS-C1-4 alkyl, SO-C1-4 alkyl, SO2-C1-4 alkyl, SO2NH-C1-4 alkyl, NHSO2-C1-4 alkyl, NHCO2-C1-4 alkyl, NHC (O) C1-4 alkyl , NO2, and C1-4 alkyl； R2 is H, or OH； or R1 and R2 can together form a carbonyl； R3 is H, C1-4 alkyl, -CN, CHF2, or CF3； R4 is H or CH3； R5 is H or deuterium； Ra is H, or CH3； Rb is H, C1-4 alkyl, or CF3； Rbb is H, C1-4 alkyl, or CF3； and pharmaceutically acceptable salts thereof.Reivindicación 1: Un compuesto de fórmula (1) en donde: A es un resto del grupo de fórmulas (2)； X es CH, o N； Z es CH, o N, siempre que X y Z no sean ambos CH； J es N o CH； Q es C-R5, siempre que J es N, o Q es N, siempre que J es CH； R1 es H, fenilo, heteroarilo, CF3, -CH=CH2, CO2-alquilo C1-4, NHBOC, NH-alquilo C1-4, N(alquilo C1-4)CO2CH2Ph, NRbC(O)Rbb, NRbSO2Rbb, C(O)N(CH3)OCH3, C(O)NRb-alquilo C1-4, C(O)NHCH2Ph(OCH3)2, -C(OH)(CH2CH=CH2)2, 3,6-dihidropiran-2-il, 2,5-dihidrofuran-2-ilo, tetrahidropiranilo, ciclopentenilo, ciclopentanilo, ciclohexenilo, ciclohexanilo, tetrahidrofuran-2-ilo, cicloheptanilo, un resto seleccionado del grupo de fórmulas (3) o alquilo de C1-6 no sustituido o sustituido, en donde el alquilo se puede sustituir con hasta dos sustituyentes, en donde un sustituyente se selecc
