Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.本發明所述為化學式(I)的化合物及其互變異構物與其藥學鹽、含有此等化合物的組合物及製劑,以及使用及製造此等化合物的方法。