EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION
发明人:
Kyunglim Lee
申请号：
US16862981
公开号：
US20200255513A1
申请日:
2020.04.30
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to a receptor-binding domain of an IgE-dependent histamine releasing factor (HRF), and a use thereof, and more specifically, ascertains, as an HRF structural region, and a FL domain and an H2 domain which bind to a receptor of HRF existing in a cell membrane, ascertains the C-terminus domain of the HRF, and ascertains that a material binding thereto inhibits IL-8 secretion, thereby determining that the FL and H2 domains and the C-terminus domain can be utilized in: the development of a therapeutic agent for treatment and prevention of HRF-related disease including allergic diseases such as asthma, rhinitis, atopic dermatitis, and anaphylaxis； inflammatory diseases such as rheumatoid arthritis； and malaria, and a method for screening for the HRF-related diseases.
