Jones, Timothy,Hadari, Yaron,Mandel-Bausch, Elizabeth,Carr, Francis,Perry, Laura
申请号：
NZ63036313
公开号：
NZ630363A
申请日:
2013.07.24
申请国别(地区):
NZ
年份:
2018
代理人:
摘要：
Disclosed is an isolated antibody, or an antigen-binding fragment thereof, which immunospecifically binds to human KIT (also known as CD117), in particular the D4 region of human KIT. The specification discloses antibodies based on mouse antibody 37M and 37C which comprise modification to the framework regions. The antibodies of the invention may be expressed in mammalian cell lines such as chinese hamster ovary (CHO) cell lines. Also disclosed is the use of said antibody in the manufacture of a medicament for treating or managing a KIT-associated disorder, wherein the KIT-associated disorder is cancer, an inflammatory condition, or fibrosis.
