The orally administered preparation containing mosapride or a salt thereof of the present invention has an immediate release layer that releases drug quickly and a sustained release that gradually releases in order to satisfy both rapid pharmacological activity and sustained 24-hour pharmacological activity simultaneously. This is a two-layer formulation consisting of two layers. High-viscosity hydroxypropylmethylcellulose (HPMC) and low-viscosity hydroxypropylmethylcellulose so that the proportion of high-viscosity hydroxypropylmethylcellulose (HPMC) increases as the release control base in the sustained-release layer (HPMC) is mixed and used, and the dissolution rate and / or the residence time in the gastrointestinal tract at different gastrointestinal tract sites having different pHs are controlled. In addition, since the present invention is a small-sized preparation having a total weight of 200 mg or less, preferably 150 to 160 mg, it has the advantage of increasing the patient's compliance.本発明のモサプリドまたはその塩を含有する経口投与製剤は、迅速な薬理活性の発現と24時間薬理活性の持続を同時に満たすために、薬物を速やかに放出させる速放層と徐々に放出させる徐放層からなる二層型製剤であり、徐放層内の放出制御基剤として高粘度のヒドロキシプロピルメチルセルロース(HPMC)の割合が多くなるように高粘度ヒドロキシプロピルメチルセルロース(HPMC)と低粘度ヒドロキシプロピルメチルセルロース(HPMC)を混合して使用し、pHが異なる各胃腸管内部位における溶出率および/または胃腸管における滞留時間を制御することを特徴とする。また、本発明は、総重量が200mg以下、好ましくは150~160mgの小さいサイズの製剤であるため、患者の服薬順応度を増進させる長所がある。