method of manufacturing nanosfer polilaktydowych with suspended or connected kowalencyjnie or jonowo matrix polilaktydow\u0105 active substance is that a solution in an organic solvent and polylactide solution of surfactant in water, the active substance in the form in olnej placed in aqueous solutionthe active substance in the form of merger or polilaktydem placed in the organic solution, then wkrapla organic phase to aqueous phase intense stirring, followed by slow evaporation of the solvent at a temperature of 20 - 35\u00b0c and under normal pressure. what separates produced nanoparticles containing the active substance.the solution is used (poly) l - laktydu of a molecular weight of from 1000 to 10000 g \/ mol, in an organic solvent at a concentration of 0.5 - 1.5 wt%. and a solution of surfactant in demineralised water conductivity below about 5 \u00b5s \/ cm at a concentration of 0.1 - 0.5 wt%.the active substance alone or in form connections with (poly) l - laktydem is brought into solution in solid form, in volume from 1.13 - 3,33% mol. with all the (poly) l - laktydu mixes at 600 - 1200 rpm for 20 - 40 minutes.after organic phase to aqueous phase by mixing wkrapla speed from 600 to 1200 rpm and continue mixing solvent to evaporate, while the process of aqueous phase and organic phase in the reactor is glass shaped spherical, volume solution of surfactant in water is 25 - 35% of the volume of the reactor.and mixing leads using the stirrer of the mixing element, whose volume is 30 - 40% of the volume of the aqueous solution of surfactant, and the aqueous phase to the organic phase, the volume ratio is 10 - 20: 1, and the process leads to temperature in the 0 - 120 degrees.Sposób wytwarzania nanosfer polilaktydowych z zawieszoną albo związaną kowalencyjnie lub jonowo z matrycą polilaktydową substancją czynną polega na tym, że sporządza się roztwór polilaktydu w rozpuszczalniku organicznym oraz roztwór surfaktantu w wodzie, substancję aktywną w formie wolnej um
