MODIFIED VARIABLE DOMAIN MOLECULES AND METHODS FOR PRODUCING AND USING THEM B

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专利权人:

GARVAN INSTITUTE OF MEDICAL RESEARCH

发明人:

CHRIST, DANIEL,DUDGEON, KIP,ROUET, ROMAIN

申请号：

CA2833404

公开号：

CA2833404A1

申请日:

2012.04.19

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

The present disclosure provides an isolated protein comprising an antibody light chain variable domain (VL) comprising at least one negatively charged amino acid positioned between residues 49 to 56 according to the numbering system of Kabat, the protein capable of binding specifically to an antigen.

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