CHEN, JOHN,FRANSSON, JOHAN,FURSOV, NATALIE,HAMEL, DAMON,MALIA, THOMAS,OBMOLOVA, GALINA,ORT, TATIANA,RYCYZYN, MICHAEL,SCULLY, MICHAEL,SWEET, RAYMOND,TEPLYAKOV, ALEXEY,WHEELER, JOHN,ALMAGRO, JUAN CARLOS
申请号：
EP13761537
公开号：
EP2825200A4
申请日:
2013.03.14
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
