BEALS JOHN MICHAEL,CUTLER JR GORDON BUTLER,DOYLE BRANDON LEE,HANSEN RYAN JOHN,LI SHUN,SHIRANI SHAHRIAR,ZHANG LIANSHAN
申请号：
ZA201008174
公开号：
ZA201008174B
申请日:
2010.11.15
申请国别(地区):
ZA
年份:
2012
代理人:
摘要：
The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and characterized by pharmacokinetic, pharmacodynamic, and/or activity peak-trough ratios of less than 2. The invention also relates to methods of providing such molecules, to pharmaceutical compositions containing them, and to their therapeutic uses.
