#$%^&*AU2013277007A120140130.pdf#####ABSTRACT The present invention relates generally to compositions for promoting in vivo and/or in vitro survival of gametes, improved function of sperm, oocyte, embryo, cell and tissue, and increased fertilization potential of sperm and oocytes, and to systems, articles and methods of preparation relating to such compositions. In particular the present invention is directed to a composition comprising: (a) an aqueous lubricant base comprising a combination of lubricious agents, and an antioxidant such as Vitamin E, in an aqueous balanced salt solution. Wherein the combination of lubricious agents comprises methylparaben, glycerol, and a cellulose selected from the group consisting of methylcellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, and hydroxypropylmethyl cellulose.