A stent-graft is coupled to an elongate flexible member at or near the distal end of the flexible member and configurable in both a collapsed configuration and an expanded configuration. The stent-graft includes an expandable stent fixed to the flexible member. A portion of the expandable stent defines a generally tubular structure in its expanded configuration. A porous polymeric mesh interfaces circumferentially about the portion of the stent defines a generally tubular structure. The mesh is expandable with the stent and carries at least one therapeutic agent. When the stent-graft is in its expanded configuration and contacts the treatment site, the at least one therapeutic agent is transferred to the treatment site by operation of contact between the stent-graft and the treatment site. The mesh can define distal and proximal openings that allow for fluid flow through the stent-graft when the stent-graft is in the expanded configuration.
