ROBERT SHALWITZ;AERPIO THERAPEUTICS INC.;JOSEPH H. GARDNER
发明人:
ROBERT SHALWITZ,JOSEPH H. GARDNER
申请号：
IL21961112
公开号：
IL219611A
申请日:
2012.05.06
申请国别(地区):
IL
年份:
2017
代理人:
摘要：
Disclosed herein are prolyl hydroxylase inhibitors that can stabilize hypoxia inducible factor-1 alpha (HIF-1±), as well as hypoxia inducible factor-2 (HIF-2). Also disclosed herein are pharmaceutical compositions comprising one or more of the disclosed compounds. Yet further disclosed are methods for stimulating the cellular immune response in a mammal such as increasing phagocytosis, for example, prolonging the life of phagocytes, inter alia, kerotyiocytes, neutrophils. As such the disclosed compounds provide methods for treating diseases that relate to the body's immune response.
