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PROCESS FOR PREPARATION OF RIFAXIMIN POLYMORPHOUS FORM ß IN SOLID STATE
专利权人:
发明人:
MAFFEI PAOLA,BACHETTI MILENA,BOTTONI GIUSEPPE,VISCOMI GIUSEPPE CLAUDIO
申请号:
IN546/MUMNP/2009
公开号:
IN259753B
申请日:
2009.03.19
申请国别(地区):
IN
年份:
2014
代理人:
摘要:
Polyols stabilize polymorphous form of rifaximin, in particular the ß form. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorph ß is stable and remains stable in time independently from the environment humidity. In this invention a method to prepare formulations constituted by pure and stable polymorphous forms able to give a pharmaceutical product is described.
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