A compound of formula [I]； ** Formula ** wherein R 1 is a cycloalkyl or an alkyl, R 22 is 1) an optionally substituted aryl, 2) an optionally substituted pyridyl, 3) an optionally substituted pyrazolopyridyl, 4) an indole optionally substituted, 5) an optionally substituted benzofuranyl, 6) an optionally substituted quinolyl, 7) an optionally substituted chromanyl, 8) an optionally substituted dihydrobenzofuranyl, 9) an optionally substituted indazolyl, 10) an optionally substituted pyrrolopyridinyl, 11) an optionally substituted benzisoxazolyl substituted, 12) an optionally substituted indolinyl, 13) an optionally substituted quinazolinyl, 14) an optionally substituted dihydroquinazolinyl, 15) an optionally substituted furopyridyl, 16) an optionally substituted isoquinolyl, 17) an optionally substituted pyrrolopyrimidinyl, 18) an optionally substituted tetrahydroquinolyl , 19) an optionally substituted tetrahydroindazolyl, 20) a tetrah optionally substituted idrocyclopentapyrazolyl, 21) an optionally substituted pyrrolyl, 22) an optionally substituted imidazolyl, 23) an optionally substituted pyrazolyl, 24) an optionally substituted thienyl, 25) an optionally substituted thiazolyl, 26) an optionally substituted triazolyl, 27) a pyrimidinyl optionally substituted, 28) an optionally substituted pyrazyl, 29) an optionally substituted imidazopyridinyl, or 30) an optionally substituted pyrrolopyrazyl, R is a C1-C4 alkyl group, one of R4 and R5 is a group selected from 1) an optionally substituted carbamoyl with an alkyl that is optionally substituted with 1 or 2 phenyls, 2) an alkyl optionally substituted with an alkoxy optionally substituted with a halogen or a phenyl； a halogen； a hydroxyl； an amino optionally substituted with 1 or 2 alkyls； or cyano； and 3) an alkoxycarbonyl, or a pharmaceutically acceptable salt thereof, the other, R3 and R6, are the same or different, a hydrogen atom, an optionally substituted carbamoyl, an optionally substituted alkyl or alkoxycar
